Regine Wendt (birth name Geyer)

@ARTICLE{10748363,
  author={Gómez, Jorge Torres and Unluturk, Bige Deniz and Lau, Florian-Lennert and Simonjan, Jennifer and Wendt, Regine and Fischer, Stefan and Dressler, Falko},
  journal={IEEE Transactions on Nanotechnology}, 
  title={DNA-Based Nanonetwork for Abnormality Detection and Localization in the Human Body}, 
  year={2024},
  volume={},
  number={},
  pages={1-15},
  keywords={Nanosensors;Location awareness;Logic gates;Computer architecture;Biomarkers;DNA;Molecular communication;Blood flow;Nanoscale devices;Interference;DNA Tiles;Nanosensors;Nano Communication;Human Circulatory System;Precision Medicine;Machine Learning;Markov Model},
  doi={10.1109/TNANO.2024.3495541}}

@ARTICLE{10594753,
  author={Pal, Saswati and Gómez, Jorge Torres and Wendt, Regine and Fischer, Stefan and Dressler, Falko},
  journal={IEEE Transactions on Molecular, Biological, and Multi-Scale Communications}, 
  title={Age of Information-Based Abnormality Detection With Decay in the Human Circulatory System}, 
  year={2024},
  volume={},
  number={},
  pages={1-1},
  keywords={Nanosensors;Logic gates;Biomarkers;Measurement;Monitoring;Semantics;Medical services;Nanosensors;Nano Communication;Human Circulatory System;Abnormality Detection;Nanosensors Decay},
  doi={10.1109/TMBMC.2024.3426951}}

@inproceedings{wendtLau2023, 
author = {Wendt, Regine and Lau, Florian-Lennert and Unger, Lena and Fischer, Stefan}, 
title = {Proteome Fingerprinting as a Localization Scheme for Nanobots}, 
year = {2023},
 isbn = {9798400700347}, 
publisher = {Association for Computing Machinery}, 
address = {New York, NY, USA}, 
url = {https://doi.org/10.1145/3576781.3608728}, 
doi = {10.1145/3576781.3608728}, 
abstract = {The localization of nanobots in the human body is a crucial element to enable diagnostic ability. Current localization schemes for nanobots primarily rely on mathematical principles, but our proposed approach offers a different perspective. In this paper, we present a completely novel idea to locate nanobots within the human body by employing local pattern recognition based on unique fingerprints. We thoroughly investigate and assess various substances in the vicinity of nanobots to develop distinctive fingerprints for all major tissues. Among the candidates, we identify the human proteome as the most suitable option due to its high tissue specificity. Through our research, we determine unique combinations of protein-coding genes, ensuring exclusive localization for each specific body region. Each tissue's optimal fingerprint consists of only two protein-coding genes, which do not intersect with other tissues, further guaranteeing accurate localization. We propose the detection of these fingerprints by using DNA-based nanonetworks, enabling targeted drug delivery and facilitating the precise localization of nanobots or their measurements within the human body.}, 
booktitle = {Proceedings of the 10th ACM International Conference on Nanoscale Computing and Communication}, 
pages = {27–32}, numpages = {6}, 
keywords = {Nanonetworks, Nano medicine, Medical application, ncn, flau, lau}, 
location = {Coventry, United Kingdom}, 
series = {NANOCOM '23} }

@inproceedings{UgerWendt2022,
  author = {Unger, Lena Felicitas and Wendt, Regine and Lau, Florian and Fischer, Stefan}, 
  title = {{ Fingerprinting via the Human Proteome as a Localization Scheme for Nanobots}}, 
  year = {2022},
 booktitle = {Student Conference 2022, Medical Engineering Science, Medical Informatics, Biomedical Engineering and Auditory Technology},
 publisher = {Infinite Science Publishing},
 organization = {Infinite Science Publishing},
 address = {L{\"u}beck},
  keywords = {flau, ncn, lau, nano, dna},
}

@INPROCEEDINGS{Lau22102,
AUTHOR={Florian-Lennert Lau and Bennet Gerlach and Regine Wendt and Stefan Fischer},
TITLE={Towards Personalized Precision Medicine Using {DNA-Based} Molecular
Communication Networks},
BOOKTITLE={9th ACM International Conference on Nanoscale Computing and Communication
2022 (ACM NanoCom'22)},
ADDRESS={Barcelona Catalunya Spain},
YEAR={2022},
month={Octobre},
days={5-7},
KEYWORDS={DNA, molecular communication, nanonetworks, nano communication,
nanomedicine, ncn, lau, flau},
ABSTRACT={One of the biggest problems in modern medicine is diagnosing
deviations from an individual norm. Most diagnostic
methods rely on comparison with a population
average. However, this does not account for personal
variations. DNA-based nanonetworks offer an alternative
approach. This paper presents a novel DNA-based
nanonetwork architecture that measures several individual
health parameters and memorizes them. Based on
that, the network determines deviations from that norm
and communicates them to an external agent."
}}

@inproceedings{inproceedings,
author = {Torres Gómez, Jorge and Wendt, Regine and Kuestner, Anke and Pitke, Ketki and Stratmann, Lukas and Dressler, Falko},
year = {2021},
month = {09},
pages = {1-7},
title = {Markov Model for the Flow of Nanobots in the Human Circulatory System},
doi = {10.1145/3477206.3477477}
}

@article{LAU2021100348,
author = {Florian-Lennert Adrian Lau and Regine Wendt and Stefan Fischer},
title = {Efficient in-message computation of prevalent mathematical operations in DNA-based nanonetworks},
journal = {Nano Communication Networks},
volume = {28},
year = {2021},
month = {June},
pages = {100348},
publisher = {Elsevier},
issn = {1878-7789},
doi = {https://doi.org/10.1016/j.nancom.2021.100348},
url = {http://www.sciencedirect.com/science/article/pii/S1878778921000090},
keywords = {flau, lau, DNA-based nanonetworks, Tile-based self-assembly, Molecular communication, DNA-computing, DNA-tiles, Nanonetworks, NCN},
abstract = {One of the most important research issues in the field of nanonetworks is the problem of constructing real networks in practice. To build such networks, one needs to create the nano-devices themselves as well as a computing and a communication mechanism. We already have developed such a concept based on DNA building blocks (so called DNA tiles), which is able to generate all three mechanisms by self-construction, basically by providing a sufficiently large number of specific DNA building blocks. Such networks are Turing complete; however, as we demonstrate in this paper, the number of required building blocks to execute computations by simulating Turing machines is large. We will show in this paper that the number can be reduced by using specific, more efficient sets of building blocks for problems that can be modeled as boolean formulas. For specific mathematical operations like And or Add, even smaller solutions/message molecules can be created. This paper presents small message molecules for frequently requested mathematical problems. We present nanonetworks for the Thres and Add operations. Thres operations can be used to register if critical concentrations of disease markers have been reached. Add forms the basis for many advanced communication protocols. Furthermore, message molecules for Mult, Xor and Inc are conceptualized. The presented message molecules are smaller and less error prone compared to the tilesets that result from more generic approaches. It is therefore more likely that they can be employed in groundbreaking wet-lab experiments in the near future.}
}

@inproceedings{Lau21DNA,
  author={Florian Lau and Regine Wendt and Stefan Fischer},
  title={{DNA-Based Molecular Communication as a Paradigm for Multi-Parameter Detection of Diseases}},
  booktitle={8th ACM International Conference on Nanoscale Computing and Communication 2021 (ACM NanoCom'21)},
  address={Virtual Conference},
  year={2021},
  month={September},
  days={7-9},
  publisher={ACM},
  keywords={flau, lau, DNA-computing, SARS-CoV-2, DNA nanonetworks, molecular communication, disease detection,NCN}
}

@inproceedings{kuestner2021age,
    author = {Kuestner, Anke and Pitke, Ketki and Torres G{\'{o}}mez, Jorge and Wendt, Regine and Fischer, Stefan and Dressler, Falko},
    title = {{Age of Information in In-Body Nano Communication Networks}},
    publisher = {ACM},
    booktitle = {8th ACM International Conference on Nanoscale Computing and Communication (ACM NanoCom 2021)},
   address = {Virtual Conference},
    year = {2021},
    month = {September},
    date = {},
    pages={},
    note = {to appear}
   }

@inproceedings{inproceedings,
author = {Kuestner, Anke and Stratmann, Lukas and Wendt, Regine and Fischer, Stefan and Dressler, Falko},
year = {2020},
month = {09},
pages = {1-2},
title = {A simulation framework for connecting in-body nano communication with out-of-body devices},
doi = {10.1145/3411295.3411308}
}

@INPROCEEDINGS{Wendt2020BVSVIS,
AUTHOR={Regine Wendt, Chris Deter and Stefan Fischer},
TITLE={BVS-Vis: A Web-based Visualizer for BloodVoyagerS},
BOOKTITLE={7th ACM International Conference on Nanoscale Computing and Communication 2020 (ACM NanoCom'20)},
ADDRESS={USA}
YEAR={2020},
MONTH={Sep},
DAYS={5},
PAGES={},
ISBN={},
URL={},
KEYWORDS={Nanonetworks; Simulation; Medical Application; Nano medicine,NCN},
}

@INPROCEEDINGS{Wendt2020MEHLISSA,
AUTHOR={Regine Wendt and Stefan Fischer},
TITLE={{MEHLISSA} - A Medical Holistic Simulation Architecture for Nanonetworks in Humans},
BOOKTITLE={7th ACM International Conference on Nanoscale Computing and Communication 2020 (ACM NanoCom'20)},
ADDRESS={USA}
YEAR={2020},
MONTH={Sep},
DAYS={5},
PAGES={},
ISBN={},
URL={},
KEYWORDS={Nanonetworks; Simulation; Medical Application; Nano medicine,NCN},
}

@inproceedings{fl2020bodyNets,
	address = {Cyberspace},
	series = {{BodyNets} '20},
	title = {Solving Generic Decision Problems by in-Message Computation in DNA-Based Molecular Nanonetworks},
	booktitle = {15th {International} {Conference} on {Body} {Area} {Networks}},
	publisher = {ICST},
	author = {Lau, Florian-Lennert and Wendt, Regine and Fischer, Stefan},
	year = {2020},
	note = {event-place: Cyberspace due to Corona},
	keywords = {nanonetworks, tile-based self-assembly, molecular communication, nanostructures, decision problems, flau,NCN}
}

@article{LAU2019,
title={Computation of decision problems within messages in DNA-tile-based molecular nanonetworks},
journal={Nano Communication Networks},
year={2019},
issn={1878-7789},
doi={10.1016/j.nancom.2019.05.002},
url={http://dx.doi.org/10.1016/j.nancom.2019.05.002},
author={Florian-Lennert Adrian Lau and Florian Büther and Regine Geyer and Stefan Fischer},
keywords={Nanonetworks, Tile-based self-assembly, Molecular communication, Nanodevices, DNA-tiles, NCN, flau},
abstract={Akyildiz et al. envisioned the use of nanonetworks as a new paradigm for computation and communication on a very small scale. We present a new approach to implement nanonetworks with molecular communication using tile-based self-assembly systems on the basis of DNA. In this model, the medium of communication is filled with DNA-based molecules. Furthermore, some nanobots are capable of creating or releasing said molecules. Once present, they can be detected by other nanobots and interpreted as messages. Some DNA-based molecule systems are capable of universal computation. We show that it is possible to construct systems, in which the evaluation to true of an arbitrary decision problem is a precondition for the assembly of a message molecule. We relocate computations from nanobots into message molecules, thereby revolutionizing the paradigm for computation in nanonetworks. This approach can be interpreted as computation inside the communication channel. We further present message molecules that only assemble if a marker has been detected at least k times, as a proof of concept.}
}

@INPROCEEDINGS{Geyer2018BloodVoyagerS,
AUTHOR={Regine Geyer and Marc Stelzner and Florian {B{\"u}ther} and Sebastian Ebers},
TITLE={{BloodVoyagerS} - Simulation of the work environment of medical nanobots},
BOOKTITLE={5th ACM International Conference on Nanoscale Computing and Communication 2018 (ACM NanoCom'18)},
ADDRESS={Reykjavik, Iceland},
YEAR={2018},
MONTH={Sep},
DAYS={5},
PAGES={},
ISBN={},
URL={https://dx.doi.org/10.1145/3233188.3233196},
KEYWORDS={Nanonetworks; Simulation; Medical Application; Nano medicine,NCN},
ABSTRACT={The simulation of nanobots in their working environment is crucial to
promote their application in the medical context. Several simulators for
nanonetworks investigate new communication paradigms at nanoscale. However,
the influence of the environment, namely the human body, on the movement
and communication of nanobots was not considered so far. We propose a
framework for simulating medical nanonetworks, which integrates a
nanonetwork simulator with a body simulator. We derive requirements for a
body model that forms the basis for our prototypical implementation of the
body simulator BloodVoyagerSas part of the network simulator ns-3. An
evaluation shows that BloodVoyagerS successfully moves nanobots in the
simulated cardiovascular system. After about 7 minutes, the nanobot
distribution reaches a dynamic equilibrium. The prototype shows promise to
provide a more realistic full-body simulation to investigate movement and
communication of nanobots in medical applications.}
}

@article{10.7717/peerj.4825,
 author = {Geyer, Regine and Madany Mamlouk, Amir},
 title = {{On the efficiency of the genetic code after frameshift mutations}},
 year = {2018},
 month = {May},
 journal = {PeerJ},
 volume = {6},
 pages = {e4825},
 issn = {2167-8359},
 url = {https://doi.org/10.7717/peerj.4825},
 doi = {10.7717/peerj.4825},
 keywords = {Standard genetic code, Overlapping codes, Frameshift mutation, Polar requirement},
 abstract = {Statistical and biochemical studies of the standard genetic code (SGC) have found evidence that the impact of mistranslations is minimized in a way that erroneous codes are either synonymous or code for an amino acid with similar polarity as the originally coded amino acid. It could be quantified that the SGC is optimized to protect this specific chemical property as good as possible. In recent work, it has been speculated that the multilevel optimization of the genetic code stands in the wider context of overlapping codes. This work tries to follow the systematic approach on mistranslations and to extend those analyses to the general effect of frameshift mutations on the polarity conservation of amino acids. We generated one million random codes and compared their average polarity change over all triplets and the whole set of possible frameshift mutations. While the natural code—just as for the point mutations—appears to be competitively robust against frameshift mutations as well, we found that both optimizations appear to be independent of each other. For both, better codes can be found, but it becomes significantly more difficult to find candidates that optimize all of these features—just like the SGC does. We conclude that the SGC is not only very efficient in minimizing the consequences of mistranslations, but rather optimized in amino acid polarity conservation for all three effects of code alteration, namely translational errors, point and frameshift mutations. In other words, our result demonstrates that the SGC appears to be much more than just “one in a million”.}
}