Dr. rer. nat. Florian-Lennert Lau

@ARTICLE{10748363,
  author={Gómez, Jorge Torres and Unluturk, Bige Deniz and Lau, Florian-Lennert and Simonjan, Jennifer and Wendt, Regine and Fischer, Stefan and Dressler, Falko},
  journal={IEEE Transactions on Nanotechnology}, 
  title={DNA-Based Nanonetwork for Abnormality Detection and Localization in the Human Body}, 
  year={2024},
  volume={},
  number={},
  pages={1-15},
  keywords={Nanosensors;Location awareness;Logic gates;Computer architecture;Biomarkers;DNA;Molecular communication;Blood flow;Nanoscale devices;Interference;DNA Tiles;Nanosensors;Nano Communication;Human Circulatory System;Precision Medicine;Machine Learning;Markov Model},
  doi={10.1109/TNANO.2024.3495541}}

@inproceedings{Stumpf2024,
  author = {Stumpf, Nils and Lau, Florian and Fischer, Stefan}, 
  title = {Systematic Review of Requirements in Medical Nanonetworks}, 
  year = {2024},
 booktitle = {Student Conference 2024, Medical Engineering Science, Medical Informatics, Biomedical Engineering and Auditory Technology},
 publisher = {Infinite Science Publishing},
 organization = {Infinite Science Publishing},
 address = {L{\"u}beck},
  keywords = {flau, ncn, lau, nano, dna},
}

@inproceedings{wendtLau2023, 
author = {Wendt, Regine and Lau, Florian-Lennert and Unger, Lena and Fischer, Stefan}, 
title = {Proteome Fingerprinting as a Localization Scheme for Nanobots}, 
year = {2023},
 isbn = {9798400700347}, 
publisher = {Association for Computing Machinery}, 
address = {New York, NY, USA}, 
url = {https://doi.org/10.1145/3576781.3608728}, 
doi = {10.1145/3576781.3608728}, 
abstract = {The localization of nanobots in the human body is a crucial element to enable diagnostic ability. Current localization schemes for nanobots primarily rely on mathematical principles, but our proposed approach offers a different perspective. In this paper, we present a completely novel idea to locate nanobots within the human body by employing local pattern recognition based on unique fingerprints. We thoroughly investigate and assess various substances in the vicinity of nanobots to develop distinctive fingerprints for all major tissues. Among the candidates, we identify the human proteome as the most suitable option due to its high tissue specificity. Through our research, we determine unique combinations of protein-coding genes, ensuring exclusive localization for each specific body region. Each tissue's optimal fingerprint consists of only two protein-coding genes, which do not intersect with other tissues, further guaranteeing accurate localization. We propose the detection of these fingerprints by using DNA-based nanonetworks, enabling targeted drug delivery and facilitating the precise localization of nanobots or their measurements within the human body.}, 
booktitle = {Proceedings of the 10th ACM International Conference on Nanoscale Computing and Communication}, 
pages = {27–32}, numpages = {6}, 
keywords = {Nanonetworks, Nano medicine, Medical application, ncn, flau, lau}, 
location = {Coventry, United Kingdom}, 
series = {NANOCOM '23} }

@inproceedings{UgerWendt2022,
  author = {Unger, Lena Felicitas and Wendt, Regine and Lau, Florian and Fischer, Stefan}, 
  title = {{ Fingerprinting via the Human Proteome as a Localization Scheme for Nanobots}}, 
  year = {2022},
 booktitle = {Student Conference 2022, Medical Engineering Science, Medical Informatics, Biomedical Engineering and Auditory Technology},
 publisher = {Infinite Science Publishing},
 organization = {Infinite Science Publishing},
 address = {L{\"u}beck},
  keywords = {flau, ncn, lau, nano, dna},
}

@inproceedings{BraGeLaMo22,
author ={Tanya Braun and Marcel Gehrke and Florian Lau and Ralf Möller},
title ={Lifting in Multi-agent Systems under Uncertainty},
booktitle ={38th Conference on Uncertainty in Artificial Intelligence (UAI 2022),
Eindhoven, Netherlands, August 1-5, 2022},
year ={2022},
 keywords={flau, lau, DNA-computing, SARS-CoV-2, DNA nanonetworks, molecular communication, disease detection, NCN}
}

@INPROCEEDINGS{Lau22102,
AUTHOR={Florian-Lennert Lau and Bennet Gerlach and Regine Wendt and Stefan Fischer},
TITLE={Towards Personalized Precision Medicine Using {DNA-Based} Molecular
Communication Networks},
BOOKTITLE={9th ACM International Conference on Nanoscale Computing and Communication
2022 (ACM NanoCom'22)},
ADDRESS={Barcelona Catalunya Spain},
YEAR={2022},
month={Octobre},
days={5-7},
KEYWORDS={DNA, molecular communication, nanonetworks, nano communication,
nanomedicine, ncn, lau, flau},
ABSTRACT={One of the biggest problems in modern medicine is diagnosing
deviations from an individual norm. Most diagnostic
methods rely on comparison with a population
average. However, this does not account for personal
variations. DNA-based nanonetworks offer an alternative
approach. This paper presents a novel DNA-based
nanonetwork architecture that measures several individual
health parameters and memorizes them. Based on
that, the network determines deviations from that norm
and communicates them to an external agent."
}}

@INPROCEEDINGS{Lau2210,
AUTHOR={Florian-Lennert Lau and Tanya Braun and Ralf {M{\"o}ller} and Stefan
Fischer},
TITLE={Using {decPOMDPcoms} to Holistically Model and Program Nanodevices and
Emergent Nanonetworks},
BOOKTITLE={9th ACM International Conference on Nanoscale Computing and Communication
2022 (ACM NanoCom'22)},
ADDRESS={Barcelona Catalunya Spain},
YEAR={2022},
month={Octobre},
days={5-7},
KEYWORDS={DecPOMDPcom, POMDP, AI systems, nanonetworks, nanomedicine, lau, ncn, flau},
ABSTRACT={In many areas like medicine, there is a wide range of promising use cases
for nanostructures and nanonetworks.
While many machine models and suggestions for individual components have
been proposed in the past, the field lacks an enveloping modeling
framework.
Researchers rarely specify a machine model for their proposed solutions,
and as a result, partial solutions are often incompatible.
With a large set of devices, a partially observable stochastic environment,
and noisy observations, many components of such nanoscale systems can be
modeled as a decentralized, partially observable, Markov decision process
with special communication capabilities (DecPOMDPcom).
We extend and specify an existing set of component-based definitions to
allow for much more precise specifications and the generation of autonomous
programs for nanobots."
}}

@inproceedings{BraFiLaMo21,
  author = {Tanya Braun and Stefan Fischer and Florian Lau and Ralf M\"oller}, 
  title = {{Lifting DecPOMDPs for Nanoscale Systems --- A Work in Progress}}, 
  booktitle = {10th International Workshop on Statistical Relational AI at the 1st International Joint Conference on Learning and Reasoning}, 
  year = {2021},
  keywords = {flau, lau,NCN},
  url = {https://arxiv.org/abs/2110.09152}
}

@article{LAU2021100348,
author = {Florian-Lennert Adrian Lau and Regine Wendt and Stefan Fischer},
title = {Efficient in-message computation of prevalent mathematical operations in DNA-based nanonetworks},
journal = {Nano Communication Networks},
volume = {28},
year = {2021},
month = {June},
pages = {100348},
publisher = {Elsevier},
issn = {1878-7789},
doi = {https://doi.org/10.1016/j.nancom.2021.100348},
url = {http://www.sciencedirect.com/science/article/pii/S1878778921000090},
keywords = {flau, lau, DNA-based nanonetworks, Tile-based self-assembly, Molecular communication, DNA-computing, DNA-tiles, Nanonetworks, NCN},
abstract = {One of the most important research issues in the field of nanonetworks is the problem of constructing real networks in practice. To build such networks, one needs to create the nano-devices themselves as well as a computing and a communication mechanism. We already have developed such a concept based on DNA building blocks (so called DNA tiles), which is able to generate all three mechanisms by self-construction, basically by providing a sufficiently large number of specific DNA building blocks. Such networks are Turing complete; however, as we demonstrate in this paper, the number of required building blocks to execute computations by simulating Turing machines is large. We will show in this paper that the number can be reduced by using specific, more efficient sets of building blocks for problems that can be modeled as boolean formulas. For specific mathematical operations like And or Add, even smaller solutions/message molecules can be created. This paper presents small message molecules for frequently requested mathematical problems. We present nanonetworks for the Thres and Add operations. Thres operations can be used to register if critical concentrations of disease markers have been reached. Add forms the basis for many advanced communication protocols. Furthermore, message molecules for Mult, Xor and Inc are conceptualized. The presented message molecules are smaller and less error prone compared to the tilesets that result from more generic approaches. It is therefore more likely that they can be employed in groundbreaking wet-lab experiments in the near future.}
}

@inproceedings{Lau21DNA,
  author={Florian Lau and Regine Wendt and Stefan Fischer},
  title={{DNA-Based Molecular Communication as a Paradigm for Multi-Parameter Detection of Diseases}},
  booktitle={8th ACM International Conference on Nanoscale Computing and Communication 2021 (ACM NanoCom'21)},
  address={Virtual Conference},
  year={2021},
  month={September},
  days={7-9},
  publisher={ACM},
  keywords={flau, lau, DNA-computing, SARS-CoV-2, DNA nanonetworks, molecular communication, disease detection,NCN}
}

@phdthesis{LAU20,
	type = {PhD Thesis},
	title = {DNA-basierte Nanonetzwerke },
	school = {Universität zu Lübeck},
	author = {Florian-Lennert Adrian Lau},
	year = {2020},
        keywords = {flau, lau, NCN},
}

@inproceedings{fl2020bodyNets,
	address = {Cyberspace},
	series = {{BodyNets} '20},
	title = {Solving Generic Decision Problems by in-Message Computation in DNA-Based Molecular Nanonetworks},
	booktitle = {15th {International} {Conference} on {Body} {Area} {Networks}},
	publisher = {ICST},
	author = {Lau, Florian-Lennert and Wendt, Regine and Fischer, Stefan},
	year = {2020},
	note = {event-place: Cyberspace due to Corona},
	keywords = {nanonetworks, tile-based self-assembly, molecular communication, nanostructures, decision problems, flau,NCN}
}

@article{LAU2019,
title={Computation of decision problems within messages in DNA-tile-based molecular nanonetworks},
journal={Nano Communication Networks},
year={2019},
issn={1878-7789},
doi={10.1016/j.nancom.2019.05.002},
url={http://dx.doi.org/10.1016/j.nancom.2019.05.002},
author={Florian-Lennert Adrian Lau and Florian Büther and Regine Geyer and Stefan Fischer},
keywords={Nanonetworks, Tile-based self-assembly, Molecular communication, Nanodevices, DNA-tiles, NCN, flau},
abstract={Akyildiz et al. envisioned the use of nanonetworks as a new paradigm for computation and communication on a very small scale. We present a new approach to implement nanonetworks with molecular communication using tile-based self-assembly systems on the basis of DNA. In this model, the medium of communication is filled with DNA-based molecules. Furthermore, some nanobots are capable of creating or releasing said molecules. Once present, they can be detected by other nanobots and interpreted as messages. Some DNA-based molecule systems are capable of universal computation. We show that it is possible to construct systems, in which the evaluation to true of an arbitrary decision problem is a precondition for the assembly of a message molecule. We relocate computations from nanobots into message molecules, thereby revolutionizing the paradigm for computation in nanonetworks. This approach can be interpreted as computation inside the communication channel. We further present message molecules that only assemble if a marker has been detected at least k times, as a proof of concept.}
}

@inproceedings{Lau1919,
author = {Bende, Philipp and Lau, Florian-Lennert Adrian and Fischer, Stefan},
title = {Error-Resistant Scaling of Three-Dimensional Nanoscale Shapes on the Basis of DNA-Tiles},
year = {2019},
isbn = {9781450368971},
publisher = {Association for Computing Machinery},
address = {New York, NY, USA},
url = {https://doi.org/10.1145/3345312.3345460},
doi = {10.1145/3345312.3345460},
booktitle = {Proceedings of the Sixth Annual ACM International Conference on Nanoscale Computing and Communication},
articleno = {Article 7},
numpages = {6},
keywords = {error-correction, nanonetworks, tile-based self-assembly, nanostructures, NCN, flau},
location = {Dublin, Ireland},
series = {NANOCOM ’19}
}

@inproceedings {lau2018Ess,
    author = {Florian-Lennert Lau, Dennis Boldt and Stefan Fischer},
    title  = {Ein drahtloses Sensornetzwerk zur Bauwerks{\"u}berwachung -- für Auto- und Eisenbahnbr{\"u}cken},
    booktitle={3. Brückenkolloquium Beurteilung, Ert{\"u}chtigung und Instandsetzung von Br{\"u}cken},
    year={2018},
    month  = {jun},
    keywords = {flau},
    volume = {3},
    pages  = {385--389},
    numpages={4},
    isbn={978-3-943563-03-0}
}

    @Article{OJIOT_2018v4i1n10_Lau,
        title     = {Techniques for the Generation of Arbitrary Three-Dimensional Shapes in Tile-Based Self-Assembly Systems},
        author    = {Florian-Lennert Lau and
                    Kristof Stahl and
                     Stefan Fischer},
        journal   = {Open Journal of Internet Of Things (OJIOT)},
        keywords = {NCN, flau},
        issn      = {2364-7108},
        year      = {2018},
        volume    = {4},
        number    = {1},
        pages     = {126--134},
        note      = {Special Issue: Proceedings of the International Workshop on Very Large Internet of Things (VLIoT 2018) in conjunction with the VLDB 2018 Conference in Rio de Janeiro, Brazil.},
        url       = {https://www.ronpub.com/ojiot/OJIOT_2018v4i1n10_Lau.html},
        publisher = {RonPub},
        bibsource = {RonPub},
        abstract = {A big challenge in nanorobotics is the construction of nanoscale objects. DNA is a bio-compatible tool to reliably and constructively create objects at the nanoscale. A possible tool to build nano-sized structures are tile-based self-assembly systems on the basis of DNA. It is challenging and time-consuming to efficiently design blueprints for the desired objects. This paper presents basic algorithms for the creation of tilesets for nxnxn-cubes in the aTAM model. Only few publications focus on three-dimensional DNA crystals. Three-dimensional shapes are likely to be of more use in nanorobotics. We present three variations: hollow cubes, cube-grids and filled cubes. The paper also presents a basic algorithm to create arbitrary, finite, connected, three-dimensional and predefined shapes at temperature 1, as well as ideas for more efficient algorithms. Among those are algorithms for spheres, ellipsoids, red blood cells and other promising designs. The algorithms and tilesets are tested/verified using a software that has been developed for the purpose of verifying three-dimensional sets of tiletypes and was influenced by the tool ISU TAS. Others can use the simulator and the algorithms to quickly create sets of tiletypes for their desired nanostructures. A long learning process may thus be omitted.}
    }

@inproceedings{Buether2017Formal,
author={Florian Büther and Florian Lau and Marc Stelzner and Sebastian Ebers},
title={A Formal Definition for Nanorobots and Nanonetworks},
booktitle={The 17th International Conference on Next Generation Wired/Wireless Advanced Networks and Systems + The 10th conference on Internet of Things and Smart Spaces (NEW2AN ruSMART 2017)},
address={St.Petersburg, Russia},
days={27},
publisher={Springer},
month={Sep},
year={2017},
url={https://dx.doi.org/10.1007/978-3-319-67380-6_20},
doi={10.1007/978-3-319-67380-6_20},
keywords={Nanorobot; Nanonetwork; Definition; Nanomachine; Machine Model,NCN,flau},
abstract={Nano computation and communication research examines nanosized devices like sensor nodes or robots. Over the last decade, it has attracted attention from many different perspectives, including material sciences, biomedical engineering, and algorithm design. With growing maturity and diversity, a common terminology is increasingly important. In this paper, we analyze the state of the art of nanoscale computational devices, and infer common requirements. We combine these with definitions for macroscale machines and robots to define Nanodevices, an umbrella term that includes all nanosized artificial devices. We derive definitions for Nanomachines and Nanorobots, each with a set of mandatory and optional components. Constraints concerning artificiality and purpose distinguish Nanodevices from nanoparticles and natural life forms. Additionally, we define a Nanonetwork as a network comprised of Nanodevices, and show the specific challenges for Medical Nanorobots and Nanonetworks. We integrate our definition into the current research of Nanodevice components with a set of examples for electronic and biological implementations.}
}

@inproceedings{Lau2017Computational,
author={Florian Lau and Florian Büther and Bennet Gerlach},
title={Computational Requirements for {Nano-Machines:} There is Limited Space at the Bottom},
booktitle={4th ACM International Conference on Nanoscale Computing and Communication 2017 (ACM NanoCom'17)},
address={Washington DC, USA},
year={2017},
days={27},
month={August},
pages={11:1--11:6},
publisher={ACM},
url={https://dx.doi.org/10.1145/3109453.3109458},
doi={10.1145/3109453.3109458},
keywords={Nanonetworks; Computational Complexity; Space-Complexity;Nano-Machines,NCN, flau},
abstract={Akyildiz et al. envisioned the use of nanonetworks as a new paradigm for computation on a very small scale. Since then, many scientists researched dependent aspects like nanoscale communication. However, most research omitted specifying the computational complexity required for their respective scenarios. To close this gap, we analyzed numerous medical scenarios and extracted the formal problems to be solved. We then compared the resulting formal problems using computational complexity theory and displayed them sorted into the classes AC 0, NC 1 and L. Lastly, we describe the benefits of our results for simulation purposes and to better assess the feasibility of nanonetwork scenarios.}
}

@inproceedings{Lau2017Embedding,
author={Florian Lau and Stefan Fischer},
title={Embedding Space-Constrained Quantum-Dot Cellular Automata in Three-Dimensional Tile-Based Self-Assembly Systems},
booktitle={4th ACM International Conference on Nanoscale Computing and Communication 2017 (ACM NanoCom'17)},
address={Washington DC, USA},
year={2017},
days={27},
month={August},
pages={22:1--22:6},
publisher={ACM},
doi={10.1145/3109453.3109457},
keywords={DNA-computing;quantum-dot cellular automaton;tile-based self-assembly, flau, NCN},
abstract={This paper proposes and motivates a combination of different technologies to enable the construction of arbitrary three-dimensional shapes at the nanoscale with certain a"-mounts of computational power. The aforementioned technologies are tile-based self-assembly systems  and quan"-tum-dot cellular automata. Both technologies are in theory capable of universal computation, while self-assembly systems may better be utilized for construction-purposes. Since the decrease in size of CMOS technology explained by Moores law approaches its lower bound due to quantum effects at the nanoscale, we find it necessary to analyze computational models like QCA to better incorporate future requirements. This paper explains the aforementioned mathematical models and defines a possible combination of both.}
}

@INPROCEEDINGS{stelzner2016precise,
author={Stelzner, Marc and Lau, Florian-Lennert and Freundt, Katja and Florian Büther and Nguyen, Mai Linh and Stamme, Cordula and Ebers, Sebastian},
title={{Precise Detection and Treatment of Human Diseases Based on Nano Networking}},
booktitle={11th International Conference on Body Area Networks (BODYNETS 2016)},
address={Turin, Italy},
year={2016},
month={December},
keywords={NCN,flau},
pages={58--64},
publisher={EAI},
url={https://dl.acm.org/citation.cfm?id=3068615.3068631},
abstract={highlight, This paper presents an elaborate scenario to and detect, motivate interdisciplinary computer science involvement in nanotechnology for medical applications. Our scenario illustrates how nanotechnology can be employed to and morbidity, potentially directly treat infectious diseases as a paradigm for human disorders associated with high and mortality. Thus, more precise techniques that monitor the presence and (host-, concentration of critical marker molecules and pathogen-derived) may be applicable at an earlier stage of the disease. Moreover, since the concentration threshold varies from person to person, continuous and diagnostic, individualized monitoring of both and detect, therapeutic measures is required. To and treat diseases directly at the affected location, we propose the usage of an in-body nano network build by nano machines. To report ndings and receive commands from outside of the body, the nano network is connected to a body area network via gateways. In this paper, we discuss the capabilities of nano machinery and architecture., presents the aforementioned network},
owner={Marc},
timestamp={2017.01.31}
}